Association of Insulin Receptor Substrate 1 (IRS-1) Y895 with Grb-2 Mediates the Insulin Signaling Involved in IRS-1-Deficient Brown Adipocyte Mitogenesis

We have recently generated immortalized fetal brown adipocyte cell lines from insulin receptor substrate 1 (IRS-1) knockout mice and demonstrated an impairment in insulin-induced lipid synthesis as compared to wild-type cell lines. In this study, we investigated the consequences of IRS-1 deficiency...

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Detalhes bibliográficos
Main Authors: Valverde, Angela M., Mur, Cecilia, Pons, Sebastián, Alvarez, Alberto M., White, Morris F., Kahn, C. Ronald, Benito, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86861/
https://ncbi.nlm.nih.gov/pubmed/11259577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.7.2269-2280.2001
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