Ras Binding Triggers Ubiquitination of the Ras Exchange Factor Ras-GRF2

Ras is a small GTPase that is activated by upstream guanine nucleotide exchange factors, one of which is Ras-GRF2. GRF2 is a widely expressed protein with several recognizable sequence motifs, including a Ras exchanger motif (REM), a PEST region containing a destruction box (DB), and a Cdc25 domain....

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Autors principals: de Hoog, Carmen L., Koehler, Jackie A., Goldstein, Marni D., Taylor, Paul, Figeys, Daniel, Moran, Michael F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC86827/
https://ncbi.nlm.nih.gov/pubmed/11238945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.6.2107-2117.2001
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