Early Embryonic Lethality in PARP-1 Atm Double-Mutant Mice Suggests a Functional Synergy in Cell Proliferation during Development

PARP-1 and ATM are both involved in the response to DNA strand breaks, resulting in induction of a signaling network responsible for DNA surveillance, cellular recovery, and cell survival. ATM interacts with double-strand break repair pathways and induces signals resulting in the control of the cell...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Murcia, Josiane Ménissier-de, Mark, Manuel, Wendling, Olivia, Wynshaw-Boris, Anthony, de Murcia, Gilbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86747/
https://ncbi.nlm.nih.gov/pubmed/11238919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1828-1832.2001
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