Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development

Mammalian cells harbor three highly homologous and widely expressed members of the ras family (H-ras, N-ras, and K-ras), but it remains unclear whether they play specific or overlapping cellular roles. To gain insight into such functional roles, here we generated and analyzed H-ras null mutant mice,...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Esteban, Luis M., Vicario-Abejón, Carlos, Fernández-Salguero, Pedro, Fernández-Medarde, Alberto, Swaminathan, Nalini, Yienger, Kate, Lopez, Eva, Malumbres, Marcos, McKay, Ron, Ward, Jerrold M., Pellicer, Angel, Santos, Eugenio
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2001
Soggetti:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86690/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.5.1444-1452.2001
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