Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development

Mammalian cells harbor three highly homologous and widely expressed members of the ras family (H-ras, N-ras, and K-ras), but it remains unclear whether they play specific or overlapping cellular roles. To gain insight into such functional roles, here we generated and analyzed H-ras null mutant mice,...

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Detalhes bibliográficos
Main Authors: Esteban, Luis M., Vicario-Abejón, Carlos, Fernández-Salguero, Pedro, Fernández-Medarde, Alberto, Swaminathan, Nalini, Yienger, Kate, Lopez, Eva, Malumbres, Marcos, McKay, Ron, Ward, Jerrold M., Pellicer, Angel, Santos, Eugenio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86690/
https://ncbi.nlm.nih.gov/pubmed/11238881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1444-1452.2001
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