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Targeted Disruption of Ras-Grf2 Shows Its Dispensability for Mouse Growth and Development

The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system tissues. Such similarities raise questions concerning the specificity and/or redundancy at the funct...

Ausführliche Beschreibung

Gespeichert in:
Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Fernández-Medarde, Alberto, Esteban, Luis M., Núñez, Alejandro, Porteros, Ángel, Tessarollo, Lino, Santos, Eugenio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2002
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133706/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11909944/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.8.2498-2504.2002
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