Targeted Disruption of Ras-Grf2 Shows Its Dispensability for Mouse Growth and Development

The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system tissues. Such similarities raise questions concerning the specificity and/or redundancy at the funct...

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Detalhes bibliográficos
Main Authors: Fernández-Medarde, Alberto, Esteban, Luis M., Núñez, Alejandro, Porteros, Ángel, Tessarollo, Lino, Santos, Eugenio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133706/
https://ncbi.nlm.nih.gov/pubmed/11909944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2498-2504.2002
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