Targeted Disruption of Ras-Grf2 Shows Its Dispensability for Mouse Growth and Development

The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system tissues. Such similarities raise questions concerning the specificity and/or redundancy at the funct...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Fernández-Medarde, Alberto, Esteban, Luis M., Núñez, Alejandro, Porteros, Ángel, Tessarollo, Lino, Santos, Eugenio
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133706/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11909944/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.8.2498-2504.2002
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