Jak3 Selectively Regulates Bax and Bcl-2 Expression To Promote T-Cell Development

Jak3-deficient mice display vastly reduced numbers of lymphoid cells. Thymocytes and peripheral T cells from Jak3-deficient mice have a high apoptotic index, suggesting that Jak3 provides survival signals. Here we report that Jak3 regulates T lymphopoiesis at least in part through its selective regu...

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Hlavní autoři: Wen, Renren, Wang, Demin, McKay, Catriona, Bunting, Kevin D., Marine, Jean-Christophe, Vanin, Elio F., Zambetti, Gerard P., Korsmeyer, Stanley J., Ihle, James N., Cleveland, John L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC86650/
https://ncbi.nlm.nih.gov/pubmed/11134353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.2.678-689.2001
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