Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

PTEN acts as a tumor suppressor, at least in part, by antagonizing phosphoinositide 3-kinase (PI3K)/Akt signaling. Here we show that Forkhead transcription factors FKHRL1 and FKHR, substrates of the Akt kinase, are aberrantly localized to the cytoplasm and cannot activate transcription in PTEN-defic...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Nakamura, Noriaki, Ramaswamy, Shivapriya, Vazquez, Francisca, Signoretti, Sabina, Loda, Massimo, Sellers, William R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86551/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11073996/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.23.8969-8982.2000
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