Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis

Ubiquitin-proteasome-mediated destruction of rate-limiting proteins is required for timely progression through the main cell cycle transitions. The anaphase-promoting complex (APC), periodically activated by the Cdh1 subunit, represents one of the major cellular ubiquitin ligases which, in Saccharom...

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Detalhes bibliográficos
Main Authors: Sørensen, Claus Storgaard, Lukas, Claudia, Kramer, Edgar R., Peters, Jan-Michael, Bartek, Jiri, Lukas, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86321/
https://ncbi.nlm.nih.gov/pubmed/11003657
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