In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions

The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor disrupted in patients with t(11;17)(q23;q21)-associated acute promyelocytic leukemia. PLZF contains an N-terminal BTB/POZ domain which is required for dimerization, transcriptional repression, formation of high-molecular...

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Main Authors: Melnick, Ari, Ahmad, K. Farid, Arai, Sally, Polinger, Adam, Ball, Helen, Borden, Katherine L., Carlile, Graeme W., Prive, Gilbert G., Licht, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2000
Assuntos:
Transcriptional Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC86130/
https://ncbi.nlm.nih.gov/pubmed/10938130
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