Insulin-Activated Protein Kinase Cβ Bypasses Ras and Stimulates Mitogen-Activated Protein Kinase Activity and Cell Proliferation in Muscle Cells

In L6 muscle cells expressing wild-type human insulin receptors (L6hIR), insulin induced protein kinase Cα (PKCα) and β activities. The expression of kinase-deficient IR mutants abolished insulin stimulation of these PKC isoforms, indicating that receptor kinase is necessary for PKC activation by in...

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Detalhes bibliográficos
Main Authors: Formisano, Pietro, Oriente, Francesco, Fiory, Francesca, Caruso, Matilde, Miele, Claudia, Maitan, Maria Alessandra, Andreozzi, Francesco, Vigliotta, Giovanni, Condorelli, Gerolama, Beguinot, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86107/
https://ncbi.nlm.nih.gov/pubmed/10938109
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