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PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1.

The small scaffold protein PED/PEA-15 is involved in several different physiologic and pathologic processes, such as cell proliferation and survival, diabetes and cancer. PED/PEA-15 exerts an anti-apoptotic function due to its ability to interfere with both extrinsic and intrinsic apoptotic pathways...

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Principais autores: Francesca Fiory, Luca Parrillo, Gregory Alexander Raciti, Federica Zatterale, Cecilia Nigro, Paola Mirra, Roberta Falco, Luca Ulianich, Bruno Di Jeso, Pietro Formisano, Claudia Miele, Francesco Beguinot
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2014-01-01
Serier:PLoS ONE
Online adgang:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113655&type=printable
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