Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function

Neurons in the mammalian suprachiasmatic nucleus (SCN) contain a cell-autonomous circadian clock that is based on a transcriptional-translational feedback loop. The basic helix-loop-helix–PAS proteins CLOCK and BMAL1 are positive regulators and drive the expression of the negative regulators CRY1 an...

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Bibliografiske detaljer
Main Authors: Shearman, Lauren P., Jin, Xiaowei, Lee, Choogon, Reppert, Steven M., Weaver, David R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86101/
https://ncbi.nlm.nih.gov/pubmed/10938103
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