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Targeted modification of the Per2 clock gene alters circadian function in mPer2(luciferase) (mPer2(Luc)) mice

Modification of the Per2 clock gene in mPer2(Luc) reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased bimodality, enhanced phase resetting to light pulses, a...

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Detaylı Bibliyografya
Yayımlandı:PLoS Comput Biol
Asıl Yazarlar: Ralph, Martin R., Shi, Shu-qun, Johnson, Carl H., Houdek, Pavel, Shrestha, Tenjin C., Crosby, Priya, O’Neill, John S., Sládek, Martin, Stinchcombe, Adam R., Sumová, Alena
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191895/
https://ncbi.nlm.nih.gov/pubmed/34048425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008987
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