Targeted modification of the Per2 clock gene alters circadian function in mPer2(luciferase) (mPer2(Luc)) mice

Modification of the Per2 clock gene in mPer2(Luc) reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased bimodality, enhanced phase resetting to light pulses, a...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Ralph, Martin R., Shi, Shu-qun, Johnson, Carl H., Houdek, Pavel, Shrestha, Tenjin C., Crosby, Priya, O’Neill, John S., Sládek, Martin, Stinchcombe, Adam R., Sumová, Alena
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191895/
https://ncbi.nlm.nih.gov/pubmed/34048425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008987
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