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Targeted modification of the Per2 clock gene alters circadian function in mPer2(luciferase) (mPer2(Luc)) mice
Modification of the Per2 clock gene in mPer2(Luc) reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased bimodality, enhanced phase resetting to light pulses, a...
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| Published in: | PLoS Comput Biol |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8191895/ https://ncbi.nlm.nih.gov/pubmed/34048425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008987 |
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