BCR-ABL Prevents c-Jun-Mediated and Proteasome-Dependent FUS (TLS) Proteolysis through a Protein Kinase CβII-Dependent Pathway

The DNA binding activity of FUS (also known as TLS), a nuclear pro-oncogene involved in multiple translocations, is regulated by BCR-ABL in a protein kinase CβII (PKCβII)-dependent manner. We show here that in normal myeloid progenitor cells FUS, although not visibly ubiquitinated, undergoes proteas...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Perrotti, Danilo, Iervolino, Angela, Cesi, Vincenzo, Cirinná, Maria, Lombardini, Silvia, Grassilli, Emanuela, Bonatti, Silvia, Claudio, Pier Paolo, Calabretta, Bruno
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86091/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10913197/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.16.6159-6169.2000
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