BCR-ABL Prevents c-Jun-Mediated and Proteasome-Dependent FUS (TLS) Proteolysis through a Protein Kinase CβII-Dependent Pathway

The DNA binding activity of FUS (also known as TLS), a nuclear pro-oncogene involved in multiple translocations, is regulated by BCR-ABL in a protein kinase CβII (PKCβII)-dependent manner. We show here that in normal myeloid progenitor cells FUS, although not visibly ubiquitinated, undergoes proteas...

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Autori principali: Perrotti, Danilo, Iervolino, Angela, Cesi, Vincenzo, Cirinná, Maria, Lombardini, Silvia, Grassilli, Emanuela, Bonatti, Silvia, Claudio, Pier Paolo, Calabretta, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC86091/
https://ncbi.nlm.nih.gov/pubmed/10913197
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