A Lipopolysaccharide-Specific Enhancer Complex Involving Ets, Elk-1, Sp1, and CREB Binding Protein and p300 Is Recruited to the Tumor Necrosis Factor Alpha Promoter In Vivo

The tumor necrosis factor alpha (TNF-α) gene is rapidly activated by lipopolysaccharide (LPS). Here, we show that extracellular signal-regulated kinase (ERK) kinase activity but not calcineurin phosphatase activity is required for LPS-stimulated TNF-α gene expression. In LPS-stimulated macrophages,...

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Main Authors: Tsai, Eunice Y., Falvo, James V., Tsytsykova, Alla V., Barczak, Amy K., Reimold, Andreas M., Glimcher, Laurie H., Fenton, Matthew J., Gordon, David C., Dunn, Ian F., Goldfeld, Anne E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86084/
https://ncbi.nlm.nih.gov/pubmed/10913190
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