A Lipopolysaccharide-Specific Enhancer Complex Involving Ets, Elk-1, Sp1, and CREB Binding Protein and p300 Is Recruited to the Tumor Necrosis Factor Alpha Promoter In Vivo

The tumor necrosis factor alpha (TNF-α) gene is rapidly activated by lipopolysaccharide (LPS). Here, we show that extracellular signal-regulated kinase (ERK) kinase activity but not calcineurin phosphatase activity is required for LPS-stimulated TNF-α gene expression. In LPS-stimulated macrophages,...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Tsai, Eunice Y., Falvo, James V., Tsytsykova, Alla V., Barczak, Amy K., Reimold, Andreas M., Glimcher, Laurie H., Fenton, Matthew J., Gordon, David C., Dunn, Ian F., Goldfeld, Anne E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2000
Soggetti:	Transcriptional Regulation
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86084/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10913190/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.16.6084-6094.2000
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