Mitochondrial Protein Import Motor: the ATPase Domain of Matrix Hsp70 Is Crucial for Binding to Tim44, while the Peptide Binding Domain and the Carboxy-Terminal Segment Play a Stimulatory Role

Antzeko izenburuak

• The Hsp70 peptide-binding domain determines the interaction of the ATPase domain with Tim44 in mitochondria
  nork: Strub, Andreas, et al.
  Argitaratua: (2002)
• The J-related Segment of Tim44 Is Essential for Cell Viability: A Mutant Tim44 Remains in the Mitochondrial Import Site, but Inefficiently Recruits mtHsp70 and Impairs Protein Translocation
  nork: Merlin, Alessio, et al.
  Argitaratua: (1999)
• Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins.
  nork: Voos, W, et al.
  Argitaratua: (1996)
• Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins.
  nork: Bömer, U, et al.
  Argitaratua: (1998)
• Mitochondrial Import Driving Forces: Enhanced Trapping by Matrix Hsp70 Stimulates Translocation and Reduces the Membrane Potential Dependence of Loosely Folded Preproteins
  nork: Geissler, Andreas, et al.
  Argitaratua: (2001)