Aldose Reductase-Deficient Mice Develop Nephrogenic Diabetes Insipidus

Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found...

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Main Authors: Ho, Horace T. B., Chung, Sookja K., Law, Janice W. S., Ko, Ben C. B., Tam, Sidney C. F., Brooks, Heddwen L., Knepper, Mark A., Chung, Stephen S. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86061/
https://ncbi.nlm.nih.gov/pubmed/10913167
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