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Postcleavage Sequence Specificity in V(D)J Recombination

Unintended DNA rearrangements in a differentiating lymphocyte can have severe, oncogenic consequences, but the mechanisms for avoiding pathogenic outcomes in V(D)J recombination are not well understood. The first level at which fidelity is instituted is in discrimination by the recombination protein...

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Hlavní autoři: Agard, Emily A., Lewis, Susanna M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC85953/
https://ncbi.nlm.nih.gov/pubmed/10866660
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