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Postcleavage Sequence Specificity in V(D)J Recombination

Unintended DNA rearrangements in a differentiating lymphocyte can have severe, oncogenic consequences, but the mechanisms for avoiding pathogenic outcomes in V(D)J recombination are not well understood. The first level at which fidelity is instituted is in discrimination by the recombination protein...

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Main Authors: Agard, Emily A., Lewis, Susanna M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC85953/
https://ncbi.nlm.nih.gov/pubmed/10866660
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