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Postcleavage Sequence Specificity in V(D)J Recombination

Unintended DNA rearrangements in a differentiating lymphocyte can have severe, oncogenic consequences, but the mechanisms for avoiding pathogenic outcomes in V(D)J recombination are not well understood. The first level at which fidelity is instituted is in discrimination by the recombination protein...

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Detalhes bibliográficos
Main Authors: Agard, Emily A., Lewis, Susanna M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85953/
https://ncbi.nlm.nih.gov/pubmed/10866660
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