Characterization of a CREB Gain-of-Function Mutant with Constitutive Transcriptional Activity In Vivo

The cyclic AMP (cAMP)-responsive factor CREB promotes cellular gene expression, following its phosphorylation at Ser133, via recruitment of the coactivator paralogs CREB-binding protein (CBP) and p300. CBP and p300, in turn, appear to mediate target gene induction via their association with RNA poly...

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Auteurs principaux: Du, Keyong, Asahara, Hiroshi, Jhala, Ulupi S., Wagner, Brandee L., Montminy, Marc
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2000
Sujets:
Transcriptional Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC85799/
https://ncbi.nlm.nih.gov/pubmed/10825195
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