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Characterization of a CREB Gain-of-Function Mutant with Constitutive Transcriptional Activity In Vivo

The cyclic AMP (cAMP)-responsive factor CREB promotes cellular gene expression, following its phosphorylation at Ser133, via recruitment of the coactivator paralogs CREB-binding protein (CBP) and p300. CBP and p300, in turn, appear to mediate target gene induction via their association with RNA poly...

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Publicado no:Mol Cell Biol
Principais autores: Du, Keyong, Asahara, Hiroshi, Jhala, Ulupi S., Wagner, Brandee L., Montminy, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2000
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85799/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10825195/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.12.4320-4327.2000
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