Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation

Eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for protein synthesis initiation factor 2 (eIF2). Composed of five subunits, it converts eIF2 from a GDP-bound form to the active eIF2-GTP complex. This is a regulatory step of translation initiation. In vi...

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Bibliographische Detailangaben
Hauptverfasser: Gomez, Edith, Pavitt, Graham D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85753/
https://ncbi.nlm.nih.gov/pubmed/10805739
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