Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation

Eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for protein synthesis initiation factor 2 (eIF2). Composed of five subunits, it converts eIF2 from a GDP-bound form to the active eIF2-GTP complex. This is a regulatory step of translation initiation. In vi...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Gomez, Edith, Pavitt, Graham D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805739/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.11.3965-3976.2000
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