Differential Binding to and Regulation of JAK2 by the SH2 Domain and N-Terminal Region of SH2-Bβ
SH2-Bβ has been shown to bind via its SH2 (Src homology 2) domain to tyrosyl-phosphorylated JAK2 and strongly activate JAK2. In this study, we demonstrate the existence of an additional binding site(s) for JAK2 within the N-terminal region of SH2-Bβ (amino acids 1 to 555) and the ability of this reg...
Guardat en:
| Publicat a: | Mol Cell Biol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
2000
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10757801/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.9.3168-3177.2000 |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|