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Differential Binding to and Regulation of JAK2 by the SH2 Domain and N-Terminal Region of SH2-Bβ

SH2-Bβ has been shown to bind via its SH2 (Src homology 2) domain to tyrosyl-phosphorylated JAK2 and strongly activate JAK2. In this study, we demonstrate the existence of an additional binding site(s) for JAK2 within the N-terminal region of SH2-Bβ (amino acids 1 to 555) and the ability of this reg...

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Udgivet i:Mol Cell Biol
Principais autores: Rui, Liangyou, Gunter, David R., Herrington, James, Carter-Su, Christin
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2000
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85611/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10757801/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.9.3168-3177.2000
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