The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding

The human progesterone receptor (PR) exists as two functionally distinct isoforms, hPRA and hPRB. hPRB functions as a transcriptional activator in most cell and promoter contexts, while hPRA is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of steroid h...

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Bibliografiska uppgifter
Huvudupphovsmän: Giangrande, Paloma H., A. Kimbrel, Erin, Edwards, Dean P., McDonnell, Donald P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
Ämnen:
Transcriptional Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC85605/
https://ncbi.nlm.nih.gov/pubmed/10757795
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