DNA Interstrand Cross-Links Induce Futile Repair Synthesis in Mammalian Cell Extracts

DNA interstrand cross-links are induced by many carcinogens and anticancer drugs. It was previously shown that mammalian DNA excision repair nuclease makes dual incisions 5′ to the cross-linked base of a psoralen cross-link, generating a gap of 22 to 28 nucleotides adjacent to the cross-link. We wis...

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Detalhes bibliográficos
Main Authors: Mu, David, Bessho, Tadayoshi, Nechev, Lubomir V., Chen, David J., Harris, Thomas M., Hearst, John E., Sancar, Aziz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85433/
https://ncbi.nlm.nih.gov/pubmed/10713168
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