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Nucleotide Excision Repair/TFIIH Helicases Rad3 and Ssl2 Inhibit Short-Sequence Recombination and Ty1 Retrotransposition by Similar Mechanisms

Eukaryotic genomes contain potentially unstable sequences whose rearrangement threatens genome structure and function. Here we show that certain mutant alleles of the nucleotide excision repair (NER)/TFIIH helicase genes RAD3 and SSL2 (RAD25) confer synthetic lethality and destabilize the Saccharomy...

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Published in:Mol Cell Biol
Main Authors: Lee, Bum-Soo, Bi, Liu, Garfinkel, David J., Bailis, Adam M.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2000
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85430/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10713167/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.7.2436-2445.2000
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