Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav

Vav works as a GDP/GTP exchange factor for Rac GTPases, thereby facilitating the transition of these proteins from the inactive (GDP-bound) into the active (GTP-bound) state. The stimulation of Vav exchange activity during cell signaling is mediated by tyrosine phosphorylation. To understand the rol...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	López-Lago, Miguel, Lee, Hyunmi, Cruz, Cristina, Movilla, Nieves, Bustelo, Xosé R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2000
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85351/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10669745/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.5.1678-1691.2000
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