Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

It is well established that cell survival signals stimulated by growth factors, cytokines, and oncoproteins are initiated by phosphoinositide 3-kinase (PI3K)- and Akt-dependent signal transduction pathways. Oncogenic Ras, an upstream activator of Akt, requires NF-κB to initiate transformation, at le...

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Hlavní autoři: Madrid, Lee V., Wang, Cun-Yu, Guttridge, Denis C., Schottelius, Arndt J. G., Baldwin, Albert S., Mayo, Marty W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2000
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC85346/
https://ncbi.nlm.nih.gov/pubmed/10669740
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