The Phosphorylation Status of a Cyclic AMP-Responsive Activator Is Modulated via a Chromatin-Dependent Mechanism

Cyclic AMP (cAMP) stimulates the expression of numerous genes via the protein kinase A (PKA)-mediated phosphorylation of CREB at Ser133. Ser133 phosphorylation, in turn, promotes recruitment of the coactivator CREB binding protein and its paralog p300, histone acetyltransferases (HATs) that have bee...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Michael, Laura F., Asahara, Hiroshi, Shulman, Andrew I., Kraus, W. Lee, Montminy, Marc
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2000
Assuntos:	Transcriptional Regulation
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85343/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10669737/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.5.1596-1603.2000
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