The Phosphorylation Status of a Cyclic AMP-Responsive Activator Is Modulated via a Chromatin-Dependent Mechanism

Cyclic AMP (cAMP) stimulates the expression of numerous genes via the protein kinase A (PKA)-mediated phosphorylation of CREB at Ser133. Ser133 phosphorylation, in turn, promotes recruitment of the coactivator CREB binding protein and its paralog p300, histone acetyltransferases (HATs) that have bee...

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Autori principali: Michael, Laura F., Asahara, Hiroshi, Shulman, Andrew I., Kraus, W. Lee, Montminy, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
Soggetti:
Transcriptional Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC85343/
https://ncbi.nlm.nih.gov/pubmed/10669737
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