Caveolin 1-Mediated Regulation of Receptor Tyrosine Kinase-Associated Phosphatidylinositol 3-Kinase Activity by Ceramide

Previous studies have indicated that proapoptotic stresses downregulate the phosphatidylinositol 3-kinase [PI(3)K]/Akt survival pathway via the activation of acid-sphingomyelinase (A-SMase) and ceramide production. Ceramide induces apoptosis and inhibits PI(3)K activity without altering expression,...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Zundel, Wayne, Swiersz, Lillian M., Giaccia, Amato
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell and Organelle Structure and Assembly
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85322/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10669728/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.5.1507-1514.2000
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