Identification of a Sequence Element from p53 That Signals for Mdm2-Targeted Degradation

The binding of Mdm2 to p53 is required for targeting p53 for degradation. p73, however, binds to Mdm2 but is refractory to Mdm2-mediated degradation, indicating that binding to Mdm2 is not sufficient for degradation. By utilizing the structural homology between p53 and p73, we generated p53-p73 chim...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Gu, Jijie, Chen, Dongli, Rosenblum, Jamie, Rubin, Rachel M., Yuan, Zhi-Min
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85255/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.4.1243-1253.2000
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