Activation of the Heterodimeric IκB Kinase α (IKKα)-IKKβ Complex Is Directional: IKKα Regulates IKKβ under Both Basal and Stimulated Conditions

Signal-induced nuclear expression of the eukaryotic NF-κB transcription factor involves the stimulatory action of select mitogen-activated protein kinase kinase kinases on the IκB kinases (IKKα and IKKβ) which reside in a macromolecular signaling complex termed the signalsome. While genetic studies...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	O'Mahony, Alison, Lin, Xin, Geleziunas, Romas, Greene, Warner C.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648602/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.4.1170-1178.2000
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