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Engineering Mouse Chromosomes with Cre-loxP: Range, Efficiency, and Somatic Applications

Chromosomal rearrangements are important resources for genetic studies. Recently, a Cre-loxP-based method to introduce defined chromosomal rearrangements (deletions, duplications, and inversions) into the mouse genome (chromosome engineering) has been established. To explore the limits of this techn...

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Autori principali: Zheng, Binhai, Sage, Marijke, Sheppeard, Elizabeth A., Jurecic, Vesna, Bradley, Allan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC85158/
https://ncbi.nlm.nih.gov/pubmed/10611243
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