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Evidence for Substrate-Specific Requirement of the Splicing Factor U2AF(35) and for Its Function after Polypyrimidine Tract Recognition by U2AF(65)

U2 snRNP auxiliary factor (U2AF) promotes U2 snRNP binding to pre-mRNAs and consists of two subunits of 65 and 35 kDa, U2AF(65) and U2AF(35). U2AF(65) binds to the polypyrimidine (Py) tract upstream from the 3′ splice site and plays a key role in assisting U2 snRNP recruitment. It has been proposed...

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Bibliografske podrobnosti
Main Authors: Guth, Sabine, Martínez, Concepción, Gaur, Rajesh K., Valcárcel, Juan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC84910/
https://ncbi.nlm.nih.gov/pubmed/10567551
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