Evidence for Substrate-Specific Requirement of the Splicing Factor U2AF(35) and for Its Function after Polypyrimidine Tract Recognition by U2AF(65)

U2 snRNP auxiliary factor (U2AF) promotes U2 snRNP binding to pre-mRNAs and consists of two subunits of 65 and 35 kDa, U2AF(65) and U2AF(35). U2AF(65) binds to the polypyrimidine (Py) tract upstream from the 3′ splice site and plays a key role in assisting U2 snRNP recruitment. It has been proposed...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Guth, Sabine, Martínez, Concepción, Gaur, Rajesh K., Valcárcel, Juan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1999
Soggetti:	Gene Expression
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84910/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10567551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.12.8263
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