Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β

Recruitment of transcriptional coactivators following ligand activation is a critical step in nuclear receptor-mediated target gene expression. Upon binding an agonist, the receptor undergoes a conformational change which facilitates the formation of a specific coactivator binding pocket within the...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Chang, Ching-yi, Norris, John D., Grøn, Hanne, Paige, Lisa A., Hamilton, Paul T., Kenan, Daniel J., Fowlkes, Dana, McDonnell, Donald P.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1999
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84907/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10567548/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.12.8226
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