Functional Independence and Interdependence of the Src Homology Domains of Phospholipase C-γ1 in B-Cell Receptor Signal Transduction

B-cell receptor (BCR)-induced activation of phospholipase C-γ1 (PLCγ1) and PLCγ2 is crucial for B-cell function. While several signaling molecules have been implicated in PLCγ activation, the mechanism coupling PLCγ to the BCR remains undefined. The role of PLCγ1 SH2 and SH3 domains at different ste...

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Bibliografiske detaljer
Main Authors: DeBell, Karen E., Stoica, Bogdan A., Verí, Maria-Concetta, Di Baldassarre, Angela, Miscia, Sebastiano, Graham, Laurie J., Rellahan, Barbara L., Ishiai, Masamichi, Kurosaki, Tomohiro, Bonvini, Ezio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84732/
https://ncbi.nlm.nih.gov/pubmed/10523627
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