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Intramolecular Regulation of Phospholipase C-γ1 by Its C-Terminal Src Homology 2 Domain

Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is a key enzyme that governs cellular functions such as gene transcription, secretion, proliferation, motility, and development. Here, we show that PLC-γ1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src homolo...

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Sonraí Bibleagrafaíochta
Main Authors: DeBell, Karen, Graham, Laurie, Reischl, Ilona, Serrano, Carmen, Bonvini, Ezio, Rellahan, Barbara
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800685/
https://ncbi.nlm.nih.gov/pubmed/17116690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01400-06
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