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Intramolecular Regulation of Phospholipase C-γ1 by Its C-Terminal Src Homology 2 Domain
Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is a key enzyme that governs cellular functions such as gene transcription, secretion, proliferation, motility, and development. Here, we show that PLC-γ1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src homolo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1800685/ https://ncbi.nlm.nih.gov/pubmed/17116690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01400-06 |
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