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Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-γ1
Phospholipase C-γ1 (PLC-γ1) contains two tandem Src homology 2 (SH2) domains. The NH(2)-terminal SH2 domain has been known to mediate the binding of PLC-γ1 to receptor protein tyrosine kinases, which then activate PLC-γ1 via phosphorylation at Y783. We now show that the phosphorylated Y783 residue (...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC555506/ https://ncbi.nlm.nih.gov/pubmed/15764700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409590102 |
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