Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27(Kip1) Activity

The mechanism by which cyclin-dependent kinase 4 (CDK4) regulates cell cycle progression is not entirely clear. Cyclin D/CDK4 appears to initiate phosphorylation of retinoblastoma protein (Rb) leading to inactivation of the S-phase-inhibitory action of Rb. However, cyclin D/CDK4 has been postulated...

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Autors principals: Tsutsui, Tateki, Hesabi, Bahar, Moons, David S., Pandolfi, Pier Paolo, Hansel, Kimberly S., Koff, Andrew, Kiyokawa, Hiroaki
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC84696/
https://ncbi.nlm.nih.gov/pubmed/10490638
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