Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27(Kip1) Activity
The mechanism by which cyclin-dependent kinase 4 (CDK4) regulates cell cycle progression is not entirely clear. Cyclin D/CDK4 appears to initiate phosphorylation of retinoblastoma protein (Rb) leading to inactivation of the S-phase-inhibitory action of Rb. However, cyclin D/CDK4 has been postulated...
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| Pubblicato in: | Mol Cell Biol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10490638/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.10.7011 |
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