Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27(Kip1) Activity

The mechanism by which cyclin-dependent kinase 4 (CDK4) regulates cell cycle progression is not entirely clear. Cyclin D/CDK4 appears to initiate phosphorylation of retinoblastoma protein (Rb) leading to inactivation of the S-phase-inhibitory action of Rb. However, cyclin D/CDK4 has been postulated...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Tsutsui, Tateki, Hesabi, Bahar, Moons, David S., Pandolfi, Pier Paolo, Hansel, Kimberly S., Koff, Andrew, Kiyokawa, Hiroaki
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 1999
Subjects:	Cell Growth and Development
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10490638/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.10.7011
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