The Ras Mutant D119N Is Both Dominant Negative and Activated

The introduction of mutation D119N (or its homolog) in the NKxD nucleotide binding motif of various Ras-like proteins produces constitutively activated or dominant-negative effects, depending on the system and assay. Here we show that Ras(D119N) has an inhibitory effect at a cell-specific concentrat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cool, Robbert H., Schmidt, Gudula, Lenzen, Christian U., Prinz, Heino, Vogt, Dorothee, Wittinghofer, Alfred
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 1999
Pynciau:
Cell Growth and Development
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC84598/
https://ncbi.nlm.nih.gov/pubmed/10454576
Tagiau: Ychwanegu Tag
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