The Ras Mutant D119N Is Both Dominant Negative and Activated

The introduction of mutation D119N (or its homolog) in the NKxD nucleotide binding motif of various Ras-like proteins produces constitutively activated or dominant-negative effects, depending on the system and assay. Here we show that Ras(D119N) has an inhibitory effect at a cell-specific concentrat...

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Bibliografiske detaljer
Main Authors: Cool, Robbert H., Schmidt, Gudula, Lenzen, Christian U., Prinz, Heino, Vogt, Dorothee, Wittinghofer, Alfred
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84598/
https://ncbi.nlm.nih.gov/pubmed/10454576
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