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SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast

mRNAs that contain premature stop codons are selectively degraded in all eukaryotes tested, a phenomenon termed “nonsense-mediated mRNA decay” (NMD) or “mRNA surveillance.” NMD may function to eliminate aberrant mRNAs so that they are not translated, because such mRNAs might encode deleterious polyp...

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Published in:Mol Cell Biol
Main Authors: Page, Michelle F., Carr, Brian, Anders, Kirk R., Grimson, Andrew, Anderson, Philip
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1999
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84455/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10454541/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.9.5943
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